Projects
Detecting the silent carrier: can we eradicate strangles from endemic premises?
Asymptomatic carrier horses of Streptococcus equi ss equi (aka 'Strangles') are often implicated as the source of new outbreaks of Strangles. Currently, there are no published studies on the proportion of horses that have been previously infected, or the proportion of those horses that remain an asymptomatic carrier under Australian management conditions.
This project will engage with a variety of horse facilities to determine the proportion of horses with antibodies to Strangles, using an ELISA test developed at the Animal Health Trust in Newmarket. Subsequent evaluation of antibody positive horses will determine the proportion of these previously infected horses that are asymptomatic carriers of Strangles. There are several methods of identifying carrier horses and these methods will be evaluated. Studies of these carrier horses will be undertaken to determine the most effective means of treating carrier animals to eliminate the bacteria and remove the risk of future outbreaks. Genomic studies of Strangles isolates from outbreaks will also be compared with isolates from carrier animals to evaluate the role of carrier animals in initiating new outbreaks of Strangles.
This project will engage with a variety of horse facilities to determine the proportion of horses with antibodies to Strangles, using an ELISA test developed at the Animal Health Trust in Newmarket. Subsequent evaluation of antibody positive horses will determine the proportion of these previously infected horses that are asymptomatic carriers of Strangles. There are several methods of identifying carrier horses and these methods will be evaluated. Studies of these carrier horses will be undertaken to determine the most effective means of treating carrier animals to eliminate the bacteria and remove the risk of future outbreaks. Genomic studies of Strangles isolates from outbreaks will also be compared with isolates from carrier animals to evaluate the role of carrier animals in initiating new outbreaks of Strangles.
